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Current IssueNovember 13, 2008
FULL TABLE OF CONTENTS | THIS WEEK IN THE JOURNAL | Audio Icon AUDIO SUMMARY
Perspective Video Screenshot Perspective Roundtable
Redesigning Primary Care
In a discussion moderated by Dr. Thomas Lee, four experts in primary care and related policy — Drs. Thomas Bodenheimer, Allan Goroll, Barbara Starfield, and Katharine Treadway — explore the current crisis in U.S. primary care and possible solutions for training, practice, compensation, and systemic change.

View Video

THE FUTURE OF PRIMARY CARE

The editors asked several experts to share their perspectives on the crisis in U.S. primary care. Their articles address the issue from six different angles.

Clinical Practice
graphic Anterior Cruciate Ligament Tear
A soccer player reacts to a defender, plants her leg, cuts to the left without contact, feels her leg give out, hears a pop, and has acute pain. The next day she presents for evaluation. How should her case be managed?   CME Exam

Audio IconListen to the full text of this article.

Molecular Origins of Cancer
graphic Inherited Susceptibility to Common Cancers
This review deals with germ-line genes that increase susceptibility to five major types of cancer — breast, lung, pancreatic, prostate, and colorectal cancer — and includes a discussion of clinical implications, especially for genetic counseling.
Case Records of the Massachusetts General Hospital
graphic A Man with Confusion and Memory Loss
A 65-year-old man was transferred to the hospital because of the recent onset of confusion and memory loss. MRI scans of the brain showed symmetric abnormalities. A CT scan of the chest disclosed an anterior mediastinal mass.   CME Exam
Original Article
graphic Mechanical Ventilation in Acute Lung Injury
Patients with acute lung injury or ARDS were randomly assigned to mechanical ventilation directed either by esophageal-pressure measurements or according to standard-of-care recommendations. The use of esophageal pressures to estimate the transpulmonary pressure significantly improved oxygenation and respiratory-system compliance.

Published Online November 11, 2008 (DOI: 10.1056/NEJMoa0708638)

Original Article
graphic General and Abdominal Adiposity and Risk of Death
This study suggests that both general and abdominal adiposity are associated with the risk of death and supports the use of waist circumference or waist-to-hip ratio for assessment of the risk of death.   Free Full Text   CME Exam
Original Article
graphic Subthalamic Nucleus Stimulation in Severe Obsessive–Compulsive Disorder
Stimulation of the subthalamic nucleus reduced the symptoms of OCD in 16 patients; however, 11 patients had serious adverse events.
Original Article
graphic Irbesartan in Patients with Heart Failure and Preserved Ejection Fraction
Patients with heart failure and a preserved ejection fraction were randomly assigned to treatment with irbesartan or placebo and followed for a mean of 49.5 months. There were no significant differences between the two study arms in the rate of the primary end point (death or hospitalization for heart failure).

Online FirstNovember 11, 2008 (DOI: 10.1056/NEJMoa0805450), in Print December 4, 2008

Editorial
PEEP Guided by Esophageal Pressure — Any Added Value?
Published Online November 11, 2008 (DOI: 10.1056/NEJMe0806637)

Correspondence
Weight Loss with a Low-Carbohydrate, Mediterranean,
or Low-Fat Diet
  Free Full Text

Tibolone in Older Postmenopausal Women

Rivaroxaban for Thromboprophylaxis

Pay-for-Performance System for English Physicians

MRSA USA300 Clone and VREF —
A U.S.–Colombian Connection?
  Free Full Text

Upcoming in Print
Published Online November 5, 2008
-A Functional Genetic Link between Distinct Developmental Language Disorders
Published Online October 30, 2008
-Cognitive Behavioral Therapy, Sertraline, or a Combination in Childhood Anxiety
FULL TABLE OF CONTENTS | THIS WEEK IN THE JOURNAL | Audio Icon AUDIO SUMMARY
Clinical Directions

Will You Change Your Practice?

The JUPITER trial studied the use of a statin to prevent cardiovascular events in asymptomatic subjects with elevated C-reactive protein.
Take a poll about this trial and contribute your comments.

Open for comments until November 26

Image of the Week

graphic

Ocular Myiasis

This 49-year-old man presented to the emergency room with a 2-day history of decreased vision in his left eye. His visual acuity in that eye was 20/200.

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All rights reserved. Electronic ISSN 1533-4406 Print ISSN 0028-4793.
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The New England Journal of Medicine (NEJM) is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice. Material is published with an emphasis on internal medicine and specialty areas including allergy/immunology, cardiology, endocrinology, gastroenterology, hematology, kidney disease, oncology, pulmonary disease, rheumatology, HIV, and infectious diseases.

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